Discovery of Novel Inhibitors of HIV-1 Reverse Transcriptase Through Virtual Screening of Experimental and Theoretical Ensembles

Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs) are potent anti-HIV chemotherapeutics. Although there are FDA-approved NNRTIs, challenges such as the development of resistance have limited their utility. Here we describe the identification of novel NNRTIs through a combination of computatio...

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Detaylı Bibliyografya
Asıl Yazarlar: Ivetac, Anthony, Swift, Sara E., Boyer, Paul L., Diaz, Arturo, Naughton, John, Young, John A. T., Hughes, Stephen H., McCammon, J. Andrew
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3999242/
https://ncbi.nlm.nih.gov/pubmed/24405985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.12277
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