Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

As the concentrations of highly consumed nutrients, particularly glucose, are generally lower in tumours than in normal tissues(1,2), cancer cells must adapt their metabolism to the tumour microenvironment. A better understanding of these adaptations might reveal cancer cell liabilities that can be...

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Bibliografiske detaljer
Main Authors: Birsoy, Kıvanç, Possemato, Richard, Lorbeer, Franziska K., Bayraktar, Erol C., Thiru, Prathapan, Yucel, Burcu, Wang, Tim, Chen, Walter W., Clish, Clary B., Sabatini, David M.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4012432/
https://ncbi.nlm.nih.gov/pubmed/24670634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13110
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