MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors

There is increasing evidence that oncogenic transformation modifies the metabolic program of cells. A common alteration is the upregulation of glycolysis, and efforts to target glycolytic enzymes for anti-cancer therapy are underway. Here, we performed a genome-wide haploid genetic screen to identif...

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Detalhes bibliográficos
Main Authors: Birsoy, Kivanc, Wang, Tim, Possemato, Richard, Yilmaz, Omer H., Koch, Catherine E., Chen, Walter W., Hutchins, Amanda W., Gultekin, Yetis, Peterson, Tim R., Carette, Jan E., Brummelkamp, Thijn R., Clish, Clary B., Sabatini, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530647/
https://ncbi.nlm.nih.gov/pubmed/23202129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2471
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