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On the Formation and Properties of Interstrand DNA-DNA Cross-links Forged by Reaction of an Abasic Site With the Opposing Guanine Residue of 5′-CAp Sequences in Duplex DNA

We recently reported that the aldehyde residue of an abasic (Ap) site in duplex DNA can generate an interstrand cross-link via reaction with a guanine residue on the opposing strand. This finding is intriguing because the highly deleterious nature of interstrand cross-links suggests that even small...

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Detalhes bibliográficos
Main Authors: Johnson, Kevin M., Price, Nathan E., Wang, Jin, Fekry, Mostafa I., Dutta, Sanjay, Seiner, Derrick R., Wang, Yinsheng, Gates, Kent S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4012394/
https://ncbi.nlm.nih.gov/pubmed/23215239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja308119q
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