Interstrand DNA–DNA Cross-Link Formation Between Adenine Residues and Abasic Sites in Duplex DNA

[Image: see text] The loss of a coding nucleobase from the structure of DNA is a common event that generates an abasic (Ap) site (1). Ap sites exist as an equilibrating mixture of a cyclic hemiacetal and a ring-opened aldehyde. Aldehydes are electrophilic functional groups that can form covalent add...

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Hauptverfasser: Price, Nathan E., Johnson, Kevin M., Wang, Jin, Fekry, Mostafa I., Wang, Yinsheng, Gates, Kent S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2014
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3954461/
https://ncbi.nlm.nih.gov/pubmed/24506784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja410969x
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