Amiloride attenuates lipopolysaccharide-accelerated atherosclerosis via inhibition of NHE1-dependent endothelial cell apoptosis

AIM: To investigate the effects of the potassium-sparing diuretic amiloride on endothelial cell apoptosis during lipopolysaccharide (LPS)-accelerated atherosclerosis. METHODS: Human umbilical vein endothelial cells (HUVECs) were exposed to LPS (100 ng/mL) in the presence of drugs tested. The activit...

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Autori principali: Cui, Gui-mei, Zhao, Yu-xi, Zhang, Na-na, Liu, Zeng-shan, Sun, Wan-chun, Peng, Qi-sheng
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011619/
https://ncbi.nlm.nih.gov/pubmed/23274414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2012.155
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