Pharmacokinetic/pharmacodynamic studies on exenatide in diabetic rats

AIM: To quantitatively evaluate the blood glucose-lowering effect of exenatide in diabetic rats. METHODS: Male Harlan-Sprague-Dawley rats were treated with high-fat diet/streptozotocin to induce type 2 diabetes. After subcutaneous administration of a single dose of exenatide (4.2, 42, or 210 μg/kg),...

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Autors principals: Li, Xin-gang, Li, Liang, Zhou, Xuan, Chen, Ye, Ren, Yu-peng, Zhou, Tian-yan, Lu, Wei
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011360/
https://ncbi.nlm.nih.gov/pubmed/22659626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2012.33
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