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Pharmacokinetic/pharmacodynamic studies on exenatide in diabetic rats
AIM: To quantitatively evaluate the blood glucose-lowering effect of exenatide in diabetic rats. METHODS: Male Harlan-Sprague-Dawley rats were treated with high-fat diet/streptozotocin to induce type 2 diabetes. After subcutaneous administration of a single dose of exenatide (4.2, 42, or 210 μg/kg),...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4011360/ https://ncbi.nlm.nih.gov/pubmed/22659626 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2012.33 |
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