Pharmacokinetic-pharmacodynamic modeling of the anticancer effect of erlotinib in a human non-small cell lung cancer xenograft mouse model

AIM: Erlotinib is used to treat non-small-cell lung cancer (NSCLC), which targets epidermal growth factor receptor (EGFR) tyrosine kinase. The aim of this study was to investigate the relationship between erlotinib plasma concentrations and phosphorylated EGFR (pEGFR) levels, as well as the relation...

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Main Authors: Wu, Qiong, Li, Meng-yao, Li, Han-qing, Deng, Chen-hui, Li, Liang, Zhou, Tian-yan, Lu, Wei
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4006468/
https://ncbi.nlm.nih.gov/pubmed/24096601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2013.101
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