Time-dependent pharmacokinetics of dexamethasone and its efficacy in human breast cancer xenograft mice: a semi-mechanism-based pharmacokinetic/pharmacodynamic model

Dexamethasone (DEX) is the substrate of CYP3A. However, the activity of CYP3A could be induced by DEX when DEX was persistently administered, resulting in auto-induction and time-dependent pharmacokinetics (pharmacokinetics with time-dependent clearance) of DEX. In this study we investigated the pha...

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Detalhes bibliográficos
Publicado no:Acta Pharmacol Sin
Main Authors: Li, Jian, Chen, Rong, Yao, Qing-yu, Liu, Sheng-jun, Tian, Xiu-yun, Hao, Chun-yi, Lu, Wei, Zhou, Tian-yan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2018
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5843834/
https://ncbi.nlm.nih.gov/pubmed/29119968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2017.153
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