Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development

P190-B RhoGAP (p190-B, also known as ARHGAP5) has been shown to play an essential role in invasion of the terminal end buds (TEBs) into the surrounding fat pad during mammary gland ductal morphogenesis. Here we report that embryos with a homozygous p190-B gene deletion exhibit major defects in embry...

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Bibliographic Details
Main Authors: Heckman, Brandy M, Chakravarty, Geetika, Vargo-Gogola, Tracy, Gonzales-Rimbau, Maria, Hadsell, Darryl L, Lee, Adrian V, Settleman, Jeffrey, Rosen, Jeffrey M
Format: Artigo
Language:Inglês
Published: 2007
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011021/
https://ncbi.nlm.nih.gov/pubmed/17662267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2007.07.002
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