Coordination of Rho and Rac GTPase function via p190B RhoGAP

The Rac GTPase regulates Rho signaling in a broad range of physiological settings and in oncogenic transformation [1–3]. Here, we report a novel mechanism by which cross-talk between Rac and Rho GTPases is achieved. Activated Rac1 binds directly to p190B RhoGAP (GTPase activating protein), a major m...

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Main Authors: Bustos, Rodrigo I., Forget, Marie-Annick, Settleman, Jeffrey E., Hansen, Steen H.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4084715/
https://ncbi.nlm.nih.gov/pubmed/18948007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2008.09.019
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