P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis

INTRODUCTION: Rho GTPases are overexpressed and hyperactivated in human breast cancers. Deficiency of p190B RhoGAP, a major inhibitor of the Rho GTPases, inhibits mouse mammary tumor virus long terminal repeat (MMTV)-Neu/ErbB2 mammary tumor formation and progression in part through effects within th...

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Detalhes bibliográficos
Main Authors: McHenry, Peter R, Sears, James C, Herrick, Matthew P, Chang, Peggy, Heckman-Stoddard, Brandy M, Rybarczyk, Megan, Chodosh, Lewis A, Gunther, Edward J, Hilsenbeck, Susan G, Rosen, Jeffrey M, Vargo-Gogola, Tracy
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3096962/
https://ncbi.nlm.nih.gov/pubmed/20860838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2643
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