P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis

INTRODUCTION: Rho GTPases are overexpressed and hyperactivated in human breast cancers. Deficiency of p190B RhoGAP, a major inhibitor of the Rho GTPases, inhibits mouse mammary tumor virus long terminal repeat (MMTV)-Neu/ErbB2 mammary tumor formation and progression in part through effects within th...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: McHenry, Peter R, Sears, James C, Herrick, Matthew P, Chang, Peggy, Heckman-Stoddard, Brandy M, Rybarczyk, Megan, Chodosh, Lewis A, Gunther, Edward J, Hilsenbeck, Susan G, Rosen, Jeffrey M, Vargo-Gogola, Tracy
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2010
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3096962/
https://ncbi.nlm.nih.gov/pubmed/20860838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2643
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge