Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells

In this study we demonstrate a new form of immunoregulation: engagement on CD4(+) T cells of the complement regulator CD46 promoted the effector potential of T helper type 1 cells (T(H)1 cells), but as interleukin 2 (IL-2) accumulated, it switched cells toward a regulatory phenotype, attenuating IL-...

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Detalhes bibliográficos
Main Authors: Cardone, John, Le Friec, Gaelle, Vantourout, Pierre, Roberts, Andrew, Fuchs, Anja, Jackson, Ian, Suddason, Tesha, Lord, Graham, Atkinson, John P, Cope, Andrew, Hayday, Adrian, Kemper, Claudia
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011020/
https://ncbi.nlm.nih.gov/pubmed/20694009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1917
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