Novel Mycosin Protease MycP(1) Inhibitors Identified by Virtual Screening and 4D Fingerprints

[Image: see text] The rise of drug-resistant Mycobacterium tuberculosis lends urgency to the need for new drugs for the treatment of tuberculosis (TB). The identification of a serine protease, mycosin protease-1 (MycP(1)), as the crucial agent in hydrolyzing the virulence factor, ESX-secretion-assoc...

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Main Authors: Hamza, Adel, Wagner, Jonathan M., Evans, Timothy J., Frasinyuk, Mykhaylo S., Kwiatkowski, Stefan, Zhan, Chang-Guo, Watt, David S., Korotkov, Konstantin V.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2014
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010288/
https://ncbi.nlm.nih.gov/pubmed/24628123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci500025r
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