Loss of Nuclear Receptor SHP Impairs but Does Not Eliminate Negative Feedback Regulation of Bile Acid Synthesis

The in vivo role of the nuclear receptor SHP in feedback regulation of bile acid synthesis was examined. Loss of SHP in mice caused abnormal accumulation and increased synthesis of bile acids due to derepression of rate-limiting CYP7A1 and CYP8B1 hydroxylase enzymes in the biosynthetic pathway. Diet...

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Huvudupphovsmän: Kerr, Thomas A., Saeki, Shigeru, Schneider, Manfred, Schaefer, Karen, Berdy, Sara, Redder, Thadd, Shan, Bei, Russell, David W., Schwarz, Margrit
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2002
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010195/
https://ncbi.nlm.nih.gov/pubmed/12062084
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