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Cholic acid mediates negative feedback regulation of bile acid synthesis in mice
Cholesterol is converted into dozens of primary and secondary bile acids through pathways subject to negative feedback regulation mediated by the nuclear receptor farnesoid X receptor (FXR) and other effectors. Disruption of the sterol 12α-hydroxylase gene (Cyp8b1) in mice prevents the synthesis of...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Clinical Investigation
2002
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC150802/ https://ncbi.nlm.nih.gov/pubmed/12393855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI16309 |
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