Cholic acid mediates negative feedback regulation of bile acid synthesis in mice

Cholesterol is converted into dozens of primary and secondary bile acids through pathways subject to negative feedback regulation mediated by the nuclear receptor farnesoid X receptor (FXR) and other effectors. Disruption of the sterol 12α-hydroxylase gene (Cyp8b1) in mice prevents the synthesis of...

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Detaylı Bibliyografya
Asıl Yazarlar: Li-Hawkins, Jia, Gåfvels, Mats, Olin, Maria, Lund, Erik G., Andersson, Ulla, Schuster, Gertrud, Björkhem, Ingemar, Russell, David W., Eggertsen, Gosta
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2002
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC150802/
https://ncbi.nlm.nih.gov/pubmed/12393855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI16309
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