Geranylgeraniol suppresses the viability of human DU145 prostate carcinoma cells and the level of HMG CoA reductase

The rate-limiting enzyme of the mevalonate pathway, 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, provides essential intermediates for the prenylation of nuclear lamins and Ras and dolichol-mediated glycosylation of growth factor receptors. The diterpene geranylgeraniol downregulates th...

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Main Authors: Fernandes, Nicolle V., Yeganehjoo, Hoda, Katuru, Rajasekhar, DeBose-Boyd, Russell A., Morris, Lindsey L., Michon, Renee, Yu, Zhi-Ling, Mo, Huanbiao
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010193/
https://ncbi.nlm.nih.gov/pubmed/24006306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1535370213492693
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