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Identification of BRAF inhibitors through in silico screening
The BRAF protein kinase, a molecule in the RAS-RAF-MEK-ERK signaling pathway, is mutated to harbor elevated kinase activity in about 7% of human cancers, making it an important therapeutic target for inhibition. Several BRAF protein kinase inhibitors have been developed through high-throughout-scree...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2008
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4010122/ https://ncbi.nlm.nih.gov/pubmed/18783202 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800539g |
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