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The Crystal Structure of BRAF in Complex with an Organoruthenium Inhibitor Reveals a Mechanism for Inhibition of an Active Form of BRAF Kinase
Substitution mutations in the BRAF serine/threonine kinase are found in a variety of human cancers. Such mutations occur in ∼70% of human malignant melanomas, and a single hyperactivating V600E mutation is found in the activation segment of the kinase domain and accounts for more than 90% of these m...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2929178/ https://ncbi.nlm.nih.gov/pubmed/19371126 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi802067u |
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