Crystal Structure of the PIM2 Kinase in Complex with an Organoruthenium Inhibitor

BACKGROUND: The serine/threonine kinase PIM2 is highly expressed in human leukemia and lymphomas and has been shown to positively regulate survival and proliferation of tumor cells. Its diverse ATP site makes PIM2 a promising target for the development of anticancer agents. To date our knowledge of...

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Detalhes bibliográficos
Main Authors: Bullock, Alex N., Russo, Santina, Amos, Ann, Pagano, Nicholas, Bregman, Howard, Debreczeni, Judit É., Lee, Wen Hwa, von Delft, Frank, Meggers, Eric, Knapp, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743286/
https://ncbi.nlm.nih.gov/pubmed/19841674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007112
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