15-deoxy-Δ(12,14)-PGJ(2) promotes inflammation and apoptosis in cardiomyocytes via the DP2/MAPK/TNFα axis

BACKGROUND: Prostaglandins (PGs), lipid autacoids derived from arachidonic acid, play a pivotal role during inflammation. PGD(2) synthase is abundantly expressed in heart tissue and PGD(2) has recently been found to induce cardiomyocyte apoptosis. PGD(2) is an unstable prostanoid metabolite; therefo...

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Main Authors: Koyani, Chintan N., Windischhofer, Werner, Rossmann, Christine, Jin, Ge, Kickmaier, Sandra, Heinzel, Frank R., Groschner, Klaus, Alavian-Ghavanini, Ali, Sattler, Wolfgang, Malle, Ernst
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4008937/
https://ncbi.nlm.nih.gov/pubmed/24698234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijcard.2014.03.086
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