CTLA4 blockade broadens the peripheral T cell receptor repertoire

PURPOSE: To evaluate the immunomodulatory effects of CTLA-4 blockade with tremelimumab in peripheral blood mononuclear cells (PBMC). EXPERIMENTAL DESIGN: We used next generation sequencing to study the complementarity determining region 3 (CDR3) from the rearranged T cell receptor (TCR) variable bet...

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Autores principales: Robert, Lidia, Tsoi, Jennifer, Wang, Xiaoyan, Emerson, Ryan, Homet, Blanca, Chodon, Thinle, Mok, Stephen, Huang, Rong Rong, Cochran, Alistair J., Comin-Anduix, Begonya, Koya, Richard C., Graeber, Thomas G., Robins, Harlan, Ribas, Antoni
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4008652/
https://ncbi.nlm.nih.gov/pubmed/24583799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-2648
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