Distinct immunological mechanisms of CTLA-4 and PD-1 blockade revealed by analyzing TCR usage in blood lymphocytes

Targeting immune inhibitory receptors has brought excitement, innovation and hope to cancer patients. Our recent work revealed the immunological effects of blocking the CTLA4 and PD-1 immune checkpoints on T cell receptor usage among peripheral blood cells, and further uncovers how the expansion of...

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Main Authors: Robert, Lidia, Harview, Christina, Emerson, Ryan, Wang, Xiaoyan, Mok, Stephen, Homet, Blanca, Comin-Anduix, Begonya, Koya, Richard C, Robins, Harlan, Tumeh, Paul C, Ribas, Antoni
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4108466/
https://ncbi.nlm.nih.gov/pubmed/25083336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.29244
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