The Ubiquitin-Specific Protease USP15 Promotes RIG-I–Mediated Antiviral Signaling by Deubiquitylating TRIM25

Ubiquitylation is an important mechanism for regulating innate immune responses to viral infections. Attachment of lysine 63 (Lys(63))–linked ubiquitin chains to the RNA sensor retinoic acid–inducible gene-I (RIG-I) by the ubiquitin E3 ligase tripartite motif protein 25 (TRIM25) leads to the activat...

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Hlavní autoři: Pauli, Eva-Katharina, Chan, Ying Kai, Davis, Meredith E., Gableske, Sebastian, Wang, May K., Feister, Katharina F., Gack, Michaela U.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4008495/
https://ncbi.nlm.nih.gov/pubmed/24399297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2004577
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