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Platelets from mice lacking the aryl hydrocarbon receptor (AHR) exhibit defective collagen-dependent signaling
BACKGROUND: We previously identified AHR as a novel regulator of megakaryocytic differentiation and polyploidization and reported that AHR-null mice have ~15% fewer platelets than WT mice, yet exhibit a dramatic, unexplained bleeding phenotype. OBJECTIVES: The current work tests our hypothesis that...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4008149/ https://ncbi.nlm.nih.gov/pubmed/24410994 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.12490 |
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