Farnesyltransferase inhibitor tipifarnib inhibits Rheb prenylation and stabilizes Bax in acute myelogenous leukemia cells

Although farnesyltransferase inhibitors have shown promising activity in relapsed lymphoma and sporadic activity in acute myelogenous leukemia, their mechanism of cytotoxicity is incompletely understood, making development of predictive biomarkers difficult. In the present study, we examined the act...

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Hauptverfasser: Ding, Husheng, McDonald, Jennifer S., Yun, Seongseok, Schneider, Paula A., Peterson, Kevin L., Flatten, Karen S., Loegering, David A., Oberg, Ann L., Riska, Shaun M., Huang, Shengbing, Sinicrope, Frank A., Adjei, Alex A., Karp, Judith E., Meng, X. Wei, Kaufmann, Scott H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ferrata Storti Foundation 2014
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007940/
https://ncbi.nlm.nih.gov/pubmed/23996484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2013.087734
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