Farnesyltransferase inhibitor tipifarnib inhibits Rheb prenylation and stabilizes Bax in acute myelogenous leukemia cells

Although farnesyltransferase inhibitors have shown promising activity in relapsed lymphoma and sporadic activity in acute myelogenous leukemia, their mechanism of cytotoxicity is incompletely understood, making development of predictive biomarkers difficult. In the present study, we examined the act...

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Bibliographic Details
Main Authors: Ding, Husheng, McDonald, Jennifer S., Yun, Seongseok, Schneider, Paula A., Peterson, Kevin L., Flatten, Karen S., Loegering, David A., Oberg, Ann L., Riska, Shaun M., Huang, Shengbing, Sinicrope, Frank A., Adjei, Alex A., Karp, Judith E., Meng, X. Wei, Kaufmann, Scott H.
Format: Artigo
Language:Inglês
Published: Ferrata Storti Foundation 2014
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007940/
https://ncbi.nlm.nih.gov/pubmed/23996484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2013.087734
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