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Tipifarnib in the treatment of newly diagnosed acute myelogenous leukemia

Farnesyltransferase inhibitors (FTIs) represent a new class of signal transduction inhibitors that block the processing of cellular polypeptides that have cysteine terminal residues and, by so doing, interdict multiple pathways involved in proliferation and survival of diverse malignant cell types....

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Bibliographic Details
Main Authors: Karp, Judith E, Lancet, Jeffrey E
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2721391/
https://ncbi.nlm.nih.gov/pubmed/19707379
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