Discovery of an Orally Efficacious Imidazo[5,1-f][1,2,4]triazine Dual Inhibitor of IGF-1R and IR

[Image: see text] This report describes the investigation of a series of 5,7-disubstituted imidazo[5,1-f][1,2,4]triazine inhibitors of insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR). Structure−activity relationship exploration and optimization leading to the identification,...

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Auteurs principaux: Jin, Meizhong, Gokhale, Prafulla C., Cooke, Andy, Foreman, Kenneth, Buck, Elizabeth, May, Earl W., Feng, Lixin, Bittner, Mark A., Kadalbajoo, Mridula, Landfair, Darla, Siu, Kam W., Stolz, Kathryn M., Werner, Douglas S., Laufer, Radoslaw S., Li, An-Hu, Dong, Hanqing, Steinig, Arno G., Kleinberg, Andrew, Yao, Yan, Pachter, Jonathan A., Wild, Robert, Mulvihill, Mark J.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2010
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007908/
https://ncbi.nlm.nih.gov/pubmed/24900240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100178g
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