Cullin 5 destabilizes Cas to inhibit Src-dependent cell transformation

Phosphorylation-dependent protein ubiquitylation and degradation provides an irreversible mechanism to terminate protein kinase signaling. Here, we report that mammary epithelial cells require cullin-5–RING–E3-ubiquitin-ligase complexes (Cul5-CRLs) to prevent transformation by a Src–Cas signaling pa...

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Autori principali: Teckchandani, Anjali, Laszlo, George S., Simó, Sergi, Shah, Khyati, Pilling, Carissa, Strait, Alexander A., Cooper, Jonathan A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Company of Biologists 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007763/
https://ncbi.nlm.nih.gov/pubmed/24284072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.127829
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