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Cullin 5 destabilizes Cas to inhibit Src-dependent cell transformation
Phosphorylation-dependent protein ubiquitylation and degradation provides an irreversible mechanism to terminate protein kinase signaling. Here, we report that mammary epithelial cells require cullin-5–RING–E3-ubiquitin-ligase complexes (Cul5-CRLs) to prevent transformation by a Src–Cas signaling pa...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Company of Biologists
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4007763/ https://ncbi.nlm.nih.gov/pubmed/24284072 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.127829 |
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