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Paradoxical relationship between RAVE (relative activity versus endocytosis) values of several opioid receptor agonists and their liability to cause dependence

AIM: To examine the relationship between the RAVE (relative activity versus endocytosis) values of opiate agonists and their dependence liability by studying several potent analgesics with special profiles in the development of physical and psychological dependence. METHODS: The effects of (−)-cis-(...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Wang, Yu-hua, Sun, Jian-feng, Tao, Yi-min, Xu, Xue-jun, Chi, Zhi-qiang, Liu, Jing-gen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007660/
https://ncbi.nlm.nih.gov/pubmed/20228826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2010.19
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