Donor hematopoiesis in mice following total lymphoid irradiation requires host T-regulatory cells for durable engraftment

Total lymphoid irradiation (TLI) with antithymocyte globulin (ATG) is a unique regimen that prepares recipients for allogeneic hematopoietic cell transplantation by targeting lymph nodes, while sparing large areas of the bone marrow. TLI is reported to increase the frequency of CD4(+)CD25(+)FoxP3(+)...

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Detalhes bibliográficos
Main Authors: Müller, Antonia M. S., Poyser, Jessica, Küpper, Natascha J., Burnett, Cassandra, Ko, Rose M., Kohrt, Holbrook E.K., Florek, Mareike, Zhang, Pei, Negrin, Robert S., Shizuru, Judith A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007614/
https://ncbi.nlm.nih.gov/pubmed/24591203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-10-530212
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