Co-transplantation of pure blood stem cells with antigen-specific but not bulk T cells augments functional immunity

Impaired immunity is a fundamental obstacle to successful allogeneic hematopoietic cell transplantation. Mature graft T cells are thought to provide protection from infections early after transplantation, but can cause life-threatening graft-vs.-host disease. Human CMV is a major pathogen after tran...

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Main Authors: Müller, Antonia M. S., Shashidhar, Sumana, Küpper, Natascha J., Kohrt, Holbrook E. K., Florek, Mareike, Negrin, Robert S., Brown, Janice M., Shizuru, Judith A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326452/
https://ncbi.nlm.nih.gov/pubmed/22440752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1120237109
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