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NOTCH2 and FLT3 gene mis-splicings are common events in patients with acute myeloid leukemia (AML): new potential targets in AML

Our previous studies revealed an increase in alternative splicing of multiple RNAs in cells from patients with acute myeloid leukemia (AML) compared with CD34(+) bone marrow cells from normal donors. Aberrantly spliced genes included a number of oncogenes, tumor suppressor genes, and genes involved...

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Detalhes bibliográficos
Main Authors: Adamia, Sophia, Bar-Natan, Michal, Haibe-Kains, Benjamin, Pilarski, Patrick M., Bach, Christian, Pevzner, Samuel, Calimeri, Teresa, Avet-Loiseau, Herve, Lode, Laurence, Verselis, Sigitas, Fox, Edward A., Galinsky, Ilene, Mathews, Steven, Dagogo-Jack, Ibiayi, Wadleigh, Martha, Steensma, David P., Motyckova, Gabriela, Deangelo, Daniel J., Quackenbush, John, Tenen, Daniel G., Stone, Richard M., Griffin, James D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007608/
https://ncbi.nlm.nih.gov/pubmed/24574459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-02-481507
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