Urokinase-type Plasminogen Activator Receptor (uPAR) Ligation Induces a Raft-localized Integrin Signaling Switch That Mediates the Hypermotile Phenotype of Fibrotic Fibroblasts

The urokinase-type plasminogen activator receptor (uPAR) is a glycosylphosphatidylinositol-linked membrane protein with no cytosolic domain that localizes to lipid raft microdomains. Our laboratory and others have documented that lung fibroblasts from patients with idiopathic pulmonary fibrosis (IPF...

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Bibliographic Details
Main Authors: Grove, Lisa M., Southern, Brian D., Jin, Tong H., White, Kimberly E., Paruchuri, Sailaja, Harel, Efrat, Wei, Ying, Rahaman, Shaik O., Gladson, Candece L., Ding, Qiang, Craik, Charles S., Chapman, Harold A., Olman, Mitchell A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Glycobiology and Extracellular Matrices
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007467/
https://ncbi.nlm.nih.gov/pubmed/24644284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.498576
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