Antibody-Drug Conjugates Targeting the Urokinase Receptor (uPAR) as a Possible Treatment of Aggressive Breast Cancer

A promising molecular target for aggressive cancers is the urokinase receptor (uPAR). A fully human, recombinant antibody that binds uPAR to form a stable complex that blocks uPA-uPAR interactions (2G10) and is internalized primarily through endocytosis showed efficacy in a mouse xenograft model of...

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Veröffentlicht in:Antibodies (Basel)
Hauptverfasser: Harel, Efrat T., Drake, Penelope M., Barfield, Robyn M., Lui, Irene, Farr-Jones, Shauna, Van’t Veer, Laura, Gartner, Zev J., Green, Evan M., Lourenço, André Luiz, Cheng, Yifan, Hann, Byron C., Rabuka, David, Craik, Charles S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6963874/
https://ncbi.nlm.nih.gov/pubmed/31694242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antib8040054
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