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Antagonistic Anti-urokinase Plasminogen Activator Receptor (uPAR) Antibodies Significantly Inhibit uPAR-mediated Cellular Signaling and Migration

Interactions between urokinase plasminogen activator receptor (uPAR) and its various ligands regulate tumor growth, invasion, and metastasis. Antibodies that bind specific uPAR epitopes may disrupt these interactions, thereby inhibiting these processes. Using a highly diverse and naïve human fragmen...

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Main Authors: Duriseti, Sai, Goetz, David H., Hostetter, Daniel R., LeBeau, Aaron M., Wei, Ying, Craik, Charles S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2010
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930687/
https://ncbi.nlm.nih.gov/pubmed/20501655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.077677
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