Antagonistic Anti-urokinase Plasminogen Activator Receptor (uPAR) Antibodies Significantly Inhibit uPAR-mediated Cellular Signaling and Migration

Interactions between urokinase plasminogen activator receptor (uPAR) and its various ligands regulate tumor growth, invasion, and metastasis. Antibodies that bind specific uPAR epitopes may disrupt these interactions, thereby inhibiting these processes. Using a highly diverse and naïve human fragmen...

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Bibliographic Details
Main Authors: Duriseti, Sai, Goetz, David H., Hostetter, Daniel R., LeBeau, Aaron M., Wei, Ying, Craik, Charles S.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930687/
https://ncbi.nlm.nih.gov/pubmed/20501655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.077677
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