Structural and Molecular Basis of the Peroxynitrite-mediated Nitration and Inactivation of Trypanosoma cruzi Iron-Superoxide Dismutases (Fe-SODs) A and B: DISPARATE SUSCEPTIBILITIES DUE TO THE REPAIR OF TYR(35) RADICAL BY CYS(83) IN Fe-SODB THROUGH INTRAMOLECULAR ELECTRON TRANSFER

Trypanosoma cruzi, the causative agent of Chagas disease, contains exclusively iron-dependent superoxide dismutases (Fe-SODs) located in different subcellular compartments. Peroxynitrite, a key cytotoxic and oxidizing effector biomolecule, reacted with T. cruzi mitochondrial (Fe-SODA) and cytosolic...

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Bibliografski detalji
Glavni autori: Martinez, Alejandra, Peluffo, Gonzalo, Petruk, Ariel A., Hugo, Martín, Piñeyro, Dolores, Demicheli, Verónica, Moreno, Diego M., Lima, Analía, Batthyány, Carlos, Durán, Rosario, Robello, Carlos, Martí, Marcelo A., Larrieux, Nicole, Buschiazzo, Alejandro, Trujillo, Madia, Radi, Rafael, Piacenza, Lucía
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
Molecular Bases of Disease
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007465/
https://ncbi.nlm.nih.gov/pubmed/24616096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.545590
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