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Intraphagosomal Peroxynitrite as a Macrophage-derived Cytotoxin against Internalized Trypanosoma cruzi: CONSEQUENCES FOR OXIDATIVE KILLING AND ROLE OF MICROBIAL PEROXIREDOXINS IN INFECTIVITY

Macrophage-derived radicals generated by the NADPH oxidase complex and inducible nitric-oxide synthase (iNOS) participate in cytotoxic mechanisms against microorganisms. Nitric oxide ((•)NO) plays a central role in the control of acute infection by Trypanosoma cruzi, the causative agent of Chagas di...

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Bibliografiske detaljer
Main Authors: Alvarez, María Noel, Peluffo, Gonzalo, Piacenza, Lucía, Radi, Rafael
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057850/
https://ncbi.nlm.nih.gov/pubmed/21098483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.167247
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