Structural and Molecular Basis of the Peroxynitrite-mediated Nitration and Inactivation of Trypanosoma cruzi Iron-Superoxide Dismutases (Fe-SODs) A and B: DISPARATE SUSCEPTIBILITIES DUE TO THE REPAIR OF TYR(35) RADICAL BY CYS(83) IN Fe-SODB THROUGH INTRAMOLECULAR ELECTRON TRANSFER

Trypanosoma cruzi, the causative agent of Chagas disease, contains exclusively iron-dependent superoxide dismutases (Fe-SODs) located in different subcellular compartments. Peroxynitrite, a key cytotoxic and oxidizing effector biomolecule, reacted with T. cruzi mitochondrial (Fe-SODA) and cytosolic...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Martinez, Alejandra, Peluffo, Gonzalo, Petruk, Ariel A., Hugo, Martín, Piñeyro, Dolores, Demicheli, Verónica, Moreno, Diego M., Lima, Analía, Batthyány, Carlos, Durán, Rosario, Robello, Carlos, Martí, Marcelo A., Larrieux, Nicole, Buschiazzo, Alejandro, Trujillo, Madia, Radi, Rafael, Piacenza, Lucía
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007465/
https://ncbi.nlm.nih.gov/pubmed/24616096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.545590
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados