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Using Mutant Cycle Analysis to Elucidate Long-Range Functional Coupling in Allosteric Receptors
The functional coupling of residues that are far apart in space is the quintessential property of allosteric receptors. Data from functional studies of allosteric receptors, such as whole-cell dose-response relations, can be used to determine if mutation to a receptor significantly impacts agonist p...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4006985/ https://ncbi.nlm.nih.gov/pubmed/22052487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-61779-334-9_6 |
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