mTOR/p70S6K signaling distinguishes routine, maintenance-level autophagy from autophagic cell death during influenza A infection

Autophagy, a stress response activated in influenza A virus infection helps the cell avoid apoptosis. However, in the absence of apoptosis infected cells undergo vastly expanded autophagy and nevertheless die in the presence of necrostatin but not of autophagy inhibitors. Combinations of inhibitors...

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Detalhes bibliográficos
Main Authors: Datan, Emmanuel, Shirazian, Alireza, Benjamin, Shawna, Matassov, Demetrius, Tinari, Antonella, Malorni, Walter, Lockshin, Richard A., Garcia-Sastre, Adolfo, Zakeri, Zahra
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005847/
https://ncbi.nlm.nih.gov/pubmed/24606695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2014.01.008
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