Sudemycin E influences alternative splicing and changes chromatin modifications

Sudemycin E is an analog of the pre-messenger RNA splicing modulator FR901464 and its derivative spliceostatin A. Sudemycin E causes the death of cancer cells through an unknown mechanism. We found that similar to spliceostatin A, sudemycin E binds to the U2 small nuclear ribonucleoprotein (snRNP) c...

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Autori principali: Convertini, Paolo, Shen, Manli, Potter, Philip M., Palacios, Gustavo, Lagisetti, Chandraiah, de la Grange, Pierre, Horbinski, Craig, Fondufe-Mittendorf, Yvonne N., Webb, Thomas R., Stamm, Stefan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
Soggetti:
Gene Regulation, Chromatin and Epigenetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005683/
https://ncbi.nlm.nih.gov/pubmed/24623796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku151
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