Comprehensive analysis of the specificity of transcription activator-like effector nucleases

A key issue when designing and using DNA-targeting nucleases is specificity. Ideally, an optimal DNA-targeting tool has only one recognition site within a genomic sequence. In practice, however, almost all designer nucleases available today can accommodate one to several mutations within their targe...

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Autori principali: Juillerat, Alexandre, Dubois, Gwendoline, Valton, Julien, Thomas, Séverine, Stella, Stefano, Maréchal, Alan, Langevin, Stéphanie, Benomari, Nassima, Bertonati, Claudia, Silva, George H., Daboussi, Fayza, Epinat, Jean-Charles, Montoya, Guillermo, Duclert, Aymeric, Duchateau, Philippe
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
Soggetti:
Synthetic Biology and Chemistry
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005648/
https://ncbi.nlm.nih.gov/pubmed/24569350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku155
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