Overcoming Transcription Activator-like Effector (TALE) DNA Binding Domain Sensitivity to Cytosine Methylation

Within the past 2 years, transcription activator-like effector (TALE) DNA binding domains have emerged as the new generation of engineerable platform for production of custom DNA binding domains. However, their recently described sensitivity to cytosine methylation represents a major bottleneck for...

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Bibliografiset tiedot
Päätekijät: Valton, Julien, Dupuy, Aurélie, Daboussi, Fayza, Thomas, Séverine, Maréchal, Alan, Macmaster, Rachel, Melliand, Kevin, Juillerat, Alexandre, Duchateau, Philippe
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2012
Aiheet:
DNA and Chromosomes
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493886/
https://ncbi.nlm.nih.gov/pubmed/23019344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C112.408864
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