Overcoming Transcription Activator-like Effector (TALE) DNA Binding Domain Sensitivity to Cytosine Methylation

Within the past 2 years, transcription activator-like effector (TALE) DNA binding domains have emerged as the new generation of engineerable platform for production of custom DNA binding domains. However, their recently described sensitivity to cytosine methylation represents a major bottleneck for...

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Autors principals: Valton, Julien, Dupuy, Aurélie, Daboussi, Fayza, Thomas, Séverine, Maréchal, Alan, Macmaster, Rachel, Melliand, Kevin, Juillerat, Alexandre, Duchateau, Philippe
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
DNA and Chromosomes
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493886/
https://ncbi.nlm.nih.gov/pubmed/23019344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C112.408864
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