Overcoming Transcription Activator-like Effector (TALE) DNA Binding Domain Sensitivity to Cytosine Methylation

Within the past 2 years, transcription activator-like effector (TALE) DNA binding domains have emerged as the new generation of engineerable platform for production of custom DNA binding domains. However, their recently described sensitivity to cytosine methylation represents a major bottleneck for...

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Bibliografski detalji
Glavni autori: Valton, Julien, Dupuy, Aurélie, Daboussi, Fayza, Thomas, Séverine, Maréchal, Alan, Macmaster, Rachel, Melliand, Kevin, Juillerat, Alexandre, Duchateau, Philippe
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
DNA and Chromosomes
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493886/
https://ncbi.nlm.nih.gov/pubmed/23019344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C112.408864
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