Overcoming Transcription Activator-like Effector (TALE) DNA Binding Domain Sensitivity to Cytosine Methylation

Within the past 2 years, transcription activator-like effector (TALE) DNA binding domains have emerged as the new generation of engineerable platform for production of custom DNA binding domains. However, their recently described sensitivity to cytosine methylation represents a major bottleneck for...

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Detalhes bibliográficos
Main Authors: Valton, Julien, Dupuy, Aurélie, Daboussi, Fayza, Thomas, Séverine, Maréchal, Alan, Macmaster, Rachel, Melliand, Kevin, Juillerat, Alexandre, Duchateau, Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
DNA and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493886/
https://ncbi.nlm.nih.gov/pubmed/23019344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C112.408864
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