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‘Null Method’ Determination of Drug Biophase Concentration
PK/PD modeling is enhanced by improvements in the accuracy of its metrics. For PK/PD modeling of drugs and biologics that interact with enzymes or receptors, the equilibrium constant of the interaction can provide critical insight. Methodologies such as radioliogand binding and isolated tissue prepa...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4005008/ https://ncbi.nlm.nih.gov/pubmed/22037914 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-011-0612-5 |
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