The Two Steps of Poly(A)-Dependent Termination, Pausing and Release, Can Be Uncoupled by Truncation of the RNA Polymerase II Carboxyl-Terminal Repeat Domain

The carboxyl-terminal repeat domain (CTD) of RNA polymerase II is thought to help coordinate events during RNA metabolism. The mammalian CTD consists of 52 imperfectly repeated heptads followed by 10 additional residues at the C terminus. The CTD is required for cleavage and polyadenylation in vitro...

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Bibliographic Details
Main Authors: Park, Noh Jin, Tsao, David C., Martinson, Harold G.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC400489/
https://ncbi.nlm.nih.gov/pubmed/15121832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.10.4092-4103.2004
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